Browsing by Subject "colon cancer"
Now showing items 1-20 of 22
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Apigenin and Naringenin Increase Apoptosis and Decrease Proliferation via Transcriptional Regulation (2014-11-26)Previous studies have shown that apigenin and naringenin (flavonoids) suppress colon carcinogenesis by inducing apoptosis and suppressing proliferation in rats. The goal of this thesis was to test the hypothesis that ...
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(2016-01-13)During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence ...
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(2013-12-05)Although significant research is currently being conducted to study human cancers, the use of in vivo models is time consuming and costly. Recent findings have documented the use of mouse intestinal crypt organoids as a ...
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(2015-10-02)Approximately 30 to 50% of colorectal cancers contain KRas mutations, which confer resistance to standard therapy and have therefore been termed “undruggable.” Since no curative treatments for KRas driven colon cancer are ...
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(Texas A&M University, 2006-08-16)This study examines the carcinogenic effect of HZE radiation and protective effects of different types of diets against colon carcinogenesis in a rat model. The effect of HZE radiation on health state and colon cancer ...
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(2020-07-27)The aryl hydrocarbon receptor (AhR) is a ligand-activated basic helix-loop-helix transcription factor that binds and senses cues from promiscuous ligands including environmental toxicants and dietary/microbiota-derived ...
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(2009-05-15)In order to test the dietary effects of bioactive compounds present in whole grains, we decided to observe the effect of varying types of sorghum bran on colon cancer promotion. We used 40 rats consuming diets containing ...
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(Texas A&M University, 2006-08-16)Colon cancer is one of the most commonly diagnosed cancers in the US, yet small intestine cancer is a rare event. While there are many similarities between these two tissues, inherent differences such as redox status, may ...
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(2012-04-26)Colon cancer exhibits the third highest cancer mortality rate of the US. Patients with inflammatory bowel disease (IBD) display a much higher risk for development of the disease. Women experience protective effects against ...
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(Texas A&M University, 2005-11-01)We have previously shown that dietary fish oil and the fiber pectin protect against colon cancer in rats by increasing apoptosis induced by reactive oxygen species (ROS) at the initiation stage of tumorigenesis. We ...
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(2012-10-19)Hormone replacement therapy and estrogen replacement therapy have shown the ability to reduce risk of colon cancer development in clinical and animal studies, but in vitro research has been unable to reproduce an estradiol ...
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(2010-07-14)One hundred thirty six men and women die every day from colon cancer in the United States (2008 statistics). Estrogen has been shown to reduce colonic tumor inflammation; however, it is unclear in the tumor development and ...
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(2013-07-03)Consumption of whole grains has been linked to reduced risk of colon cancer. This study determined estrogenic activity of sorghum phenolic extracts of different phenolic profiles and identified possible estrogenic compounds ...
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(2010-01-16)Microarray technology has become a dynamic tool in gene expression analysis because it allows for the simultaneous measurement of thousands of gene expressions. Uniqueness in experimental units and microarray data platforms, ...
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(2012-12-05)We have hypothesized that dietary modulation of intestinal miRNA expression may contribute to the chemoprotective effects of nutritional bioactives (fish oil and pectin). Using a rat colon carcinogen model, we determined ...
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(2011-10-21)To understand the mechanisms of transcriptional regulation of PXR, we performed yeast two-hybrid screenings to search for PXR-interacting proteins in a human liver cDNA library using the PXR ligand binding domain as the ...
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(2010-01-16)Recent experiments are bringing to the fore more and more information about the effects of different treatments on the gene expression of different genes. The results obtained from these experiments show that some definite ...
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(Texas A&M University, 2005-11-01)This dissertation examines the effects of postharvest treatment and processing on biologically active compounds of orange juice, and ??Rio Red?? grapefruit and their ability to prevent chemically induced colon cancer in ...
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(2013-11-22)Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated colon cancer compared to post-menopausal women and men. The studies presented herein aim to determine the ...
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(2012-08-30)The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase integral in regulating cell growth, survival, and migration. EGFR signaling, which is dependent on localization of the receptor within ...